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Levofloxacin has the potential to form stable coordination compounds with many metal ions. This in vitro chelation potential has the following formation order: Al+3 > Cu+2 > Zn+2 > Mg+2 > Ca+2 .During clinical trials, elevations in ALT and AST to greater than 5 times ULN occurred in 20% and 13%, respectively, of patients seropositive for hepatitis B and/or C. Therapy was discontinued in 3% of coinfected patients due to liver or biliary system disorders.

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Provide your physician with a list of all the medicine, including herbs and non-prescription drugs, or dietary supplements that you are using. Do let them know if you smoke, drink alcohol, or use any of the illegal drugs or drinks with caffeine or alcohol. Some of those items may also interact with your medicine, causing undesired consequenses. Please always consult with your health care professional prior to sping or starting any of your medicines.

Common (1% to 10%): Nervousness (included agitation/hyperactive), abnormal dreams, severe depression, hallucinationsnausea, Warfarin (Coumadin) numbness or tingling in the hands or feet

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altered hearing such as loss of hearing or ringing in earsAll dose strengths contain: crospovidone, hydroxypropyl cellulose, hypromellose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, silicon dioxide, titanium dioxide. Dose strength-specific ingredients include: 5 mg—ferric oxide yellow, lactose monohydrate; 30 mg—lactose monohydrate; 35 mg—ferric oxide red, ferric oxide yellow, lactose monohydrate; 75 mg—ferric oxide red; 150 mg—FD&C blue #2 aluminum lake.

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The European Commission granted a marketing authorisation valid throughout the European Union for Sustiva on 28 May 1999.

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